Build two opposite centers
Make one 2×2 center, then build its opposite color on the other side. A 4×4 has no fixed centers, so keep the color scheme consistent.
Learn the 4×4 reduction method: build centers, pair edges, solve it like a 3×3, and handle OLL and PLL parity.

Rw turns the two right layers, Uw the two upper layers, r an inner slice, and x the whole cube.
Make one 2×2 center, then build its opposite color on the other side. A 4×4 has no fixed centers, so keep the color scheme consistent.
Hold the two solved centers on the left and right. Build the remaining four centers without breaking the first pair.
Join two edge pieces with matching colors, store the completed pair in a safe layer, and continue until all 12 edges are paired.
Treat each 2×2 center as one center and every edge pair as one edge. Use your normal 3×3 method.
If one last-layer edge pair appears flipped, hold it at the front of the upper layer and perform the parity algorithm.
Rw U2 x Rw U2 Rw U2 Rw′ U2 Lw U2 Rw′ U2 Rw U2 Rw′ U2 Rw′If only two edge pairs remain swapped, hold them opposite each other and perform the sequence.
r2 U2 r2 Uw2 r2 Uw2